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Side effects are often most noticeable when starting treatment or increasing the dose
Palau-Rodriguez M, Tulipani S, Isabel Queipo-Ortuno M, Urpi-Sarda M, Tinahones FJ, Andres-Lacueva C
Additionally, the anti-Parkinsons drug rotigotine increases striatal astrocytic MT-1/2 and protects nigral DA neurons in a 6-hydroxydopamine (6-OHDA) mouse model of PD through activation of astrocytic 5-HT1A receptors, highlighting its potential as a neuroprotective therapy against dopaminergic degeneration (Isooka et al., 2020)
Kidney Function There are concerns that taking it may have a negative effect on kidney function, particularly in people with pre-existing kidney disease
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